Nuclear Organization in Development and Disease

This book draws together contributions from scientists who are studying, from different perspectives, the nine human diseases that have been linked to mutations in genes encoding components of the nuclear envelope: cell and developmental biologists, structural biologists, geneticists and clinical scientists. Topics include how nuclear structure and location within a nucleus affect gene expression, chromatin organization and cell differentiation; the nature of the interactions between the nuclear envelope and the cytoskeleton; and the extent to which the cytoskeleton mediates communication between the cell membrane and nucleus in regulating gene expression, and whether disruption of such communication might underlie the disease processes.